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PostPosted: Fri Oct 29, 2010 7:56 am 
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Cancer cells 'can be shielded'

Cancer cells can be shielded against the effects of chemotherapy by the body's own stress defences, a study has shown.

The findings add to growing evidence that inflammation, part of the immune response, is linked to cancer.

Scientists studied mice with lymphoma, a cancer of the lymph system, that were treated with a chemotherapy drug.

They discovered some tumour cells found refuge in the lymphoma, an organ where immune cells mature. There they were shielded from the drug by an "anti-stress" immune system molecule generated by healthy cells. The signalling molecule, interleukin-6 (IL-6), allowed the cancer cells to persist in the thymus.

Further experiments showed that human liver cancer cells exposed to the chemotherapy agent doxorubicin also produced IL-6. When chemotherapy was combined with a treatment that blocked IL-6, the cancer cells were more likely to die. IL-6 is already linked to harmful inflammation and autoimmune conditions. Anti-IL-6 therapies are now in development for treating patients with rheumatoid arthritis.

Researcher Dr Michael Hemann, from Massachusetts Institute of Technology in Boston, US, said the findings made sense from the point of view of organ survival in the face of stress.

To maintain itself, an organ had to respond to stressful conditions, he pointed out. He added: "In this case, the stress response is to chemo. The chemotherapy kills tumour cells while it elicits stress responses that protect a subset of tumour cells in select locations from drug action."

The findings are reported in the journal Cell. Dr Hemann's team wrote: "While significant progress has been made in the application of chemotherapy in the past 40 years, most chemotherapeutic regimens ultimately fail to cure patients. Even tumours that show dramatic initial responses to therapy frequently relapse as chemoresistant malignancies."

Dr Hemann said most approaches to tackling cancer involved "single agents".

"Our data suggest that a combination of DNA-damaging chemotherapy or radiation plus treatments designed to block pro-survival pathways would be the most potent therapy," he added. ... 280125383A

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PostPosted: Sat Oct 30, 2010 7:23 am 
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Spice in Curry Could Prevent Liver Damage

ScienceDaily (Oct. 29, 2010) — Curcumin, a chemical that gives curry its zing, holds promise in preventing or treating liver damage from an advanced form of a condition known as fatty liver disease, new Saint Louis University research suggests.

Curcurmin is contained in turmeric, a plant used by the Chinese to make traditional medicines for thousands of years. SLU's recent study highlights its potential in countering an increasingly common kind of fatty liver disease called non-alcoholic steatohepatitis (NASH). Linked to obesity and weight gain, NASH affects 3 to 4 percent of U.S. adults and can lead to a type of liver damage called liver fibrosis and possibly cirrhosis, liver cancer and death.

"My laboratory studies the molecular mechanism of liver fibrosis and is searching for natural ways to prevent and treat this liver damage," said Anping Chen, Ph.D., corresponding author and director of research in the pathology department of Saint Louis University.

"While research in an animal model and human clinical trials are needed, our study suggests that curcumin may be an effective therapy to treat and prevent liver fibrosis, which is associated with non-alcoholic steatohepatitis (NASH)."

High levels of blood leptin, glucose and insulin are commonly found in human patients with obesity and type 2 diabetes, which might contribute to NASH-associated liver fibrosis.

Chen's most recent work tested the effect of curcumin on the role of high levels of leptin in causing liver fibrosis in vitro, or in a controlled lab setting.

"Leptin plays a critical role in the development of liver fibrosis," he said.

High levels of leptin activate hepatic stellate cells, which are the cells that cause overproduction of the collagen protein, a major feature of liver fibrosis. The researchers found that among other activities, curcumin eliminated the effects of leptin on activating hepatic stellate cells, which short-circuited the development of liver damage.

The findings were published in the September issue of Endocrinology. ... 152755.htm

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PostPosted: Fri Nov 19, 2010 12:55 pm 
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Discover the secret of beauty on a budget with turmeric

(NaturalNews) Instead of paying high prices for chemical-laden cosmetics and creams, consider turmeric. This humble, economical, and easily accessible herb has been time tested throughout Asia for promoting natural beauty.

Turmeric (Curcuma longa) is native to Southeast Asia. This golden-orange rhizome is dried and ground into a powdered spice with many culinary, medicinal, and cosmetic uses. Called khamin in Thai, turmeric is one of the key ingredients utilized in traditional skin care. When the fresh rhizome is crushed, an oil is produced that lends an effective natural moisturizer with antiseptic qualities. Turmeric is an important element in Thai Spa herbal wrap treatments, serving as a potent antibacterial skin freshener.

Turmeric is also a powerful blood purifier and liver cleanser. Taken internally, turmeric helps to detoxify the system which contributes to a radiant complexion. Strong antioxidant and anti-inflammatory properties curb aging by minimizing wrinkles and sagging of the skin.

Of the many cosmetic uses, turmeric is famous for healing:

Acne, eczema, and psoriasis
Uneven pigmentation
Dark circles and puffiness around the eyes
Cracked soles of the feet
Lackluster skin

(*Note: In the recipes below it is best to use only organic raw certified milk.)

To minimize dark circles under eyes, whisk together 1 tablespoon whole milk, 1/8 teaspoon turmeric powder, and 1 teaspoon smooth almond butter. Apply under eyes and let it set for 10 minutes. Gently remove with cotton ball soaked in milk.

For a nourishing moisturizing mask, combine 4 macadamia nuts, 1/8 teaspoon turmeric powder, 2 drops lemon juice, and 3 tablespoons milk in a coffee grinder. Process until smooth. Apply to face and let it set for 20 minutes. Rinse with warm water.

A pinch of turmeric powder blended with sesame oil keeps gums healthy. Massage the mixture into gums for 5-10 minutes and rinse with warm water.

A simple recipe for illuminating a dull complexion is found in Natural Beauty Secrets from India:

Combine 1 teaspoon gram flour with 1/4 teaspoon turmeric powder. Add a 1/2 teaspoon each of olive oil and milk plus 4-5 drops of lemon juice. Apply to skin and leave it on for 25-30 minutes. Rinse with cool water.

Since turmeric's color can stain, keep away from hairline. To remove any coloring from skin, simply rub a milk soaked cotton ball on affected area.

Take charge of your natural beauty. Encourage luminous heath inside and out with the amazing properties of turmeric.

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PostPosted: Tue Dec 14, 2010 9:06 am 
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Carnitine, Curcumin and DHA - Nutrient trio boosts brain health and cognition

(NaturalNews) Cognitive decline and memory loss are considered a normal function of aging by millions of people. A `senior moment` is the term coined to describe momentary forgetfulness that some people experience from time to time. Lapses in memory are not normal and are a strong indicator of brain decline that typically progresses over a period of several decades. Our brain requires nutrition, healthy blood flow and oxygen just as any organ to remain `plastic` and be able to function at optimal capacity. Years of dietary abuse and exposure to toxic household and environmental chemicals cause brain stress, inflammation and insulin resistance. A trio of super nutrients demonstrates the capacity to improve brain health and lower the risk of cognitive decline.

Memory Decline is Not a Normal Part of Aging

The brain receives 20% of your body`s supply of freshly oxygenated blood. When this supply is restricted through narrowing of the arteries and inflammation, the brain experiences stress and cognition is diminished. Any nutrient that can specifically target and increase the flow of blood and oxygen to the brain can slow or even reverse brain decline and restore memory and learning abilities.

Carnitine Promotes Brain Rejuvenation

Carnitine is a naturally occurring amino acid that has been shown to benefit brain health, improve stress tolerance and protect against excitotoxic damage to brain neurons. Carnitine helps to prevent the nerve-related wear and tear that promotes the buildup of amyloid plaque and is associated with Alzheimer`s disease. The results of a study completed at the University of Milan demonstrated that the amino acid inhibits the secretion of nerve cell proteins that become tangled plaque in the brain.

Curcumin Reduces Brain Mediated Stress

The normal process of metabolic function creates free radicals that are damaging to the brain. We can limit the effects of free radicals by eating a naturally raw diet filled with fresh vegetables, nuts and seeds and limiting stressful situations. Super nutrients such as curcumin can help keep free radicals at bay by absorbing the impact of these damaging particles. The results of information published in the journal Neurotoxicity show that curcumin deactivates one of the most damaging free radicals known as peroxynitrite by boosting antioxidant defenses in the brain and lowering inflammatory responses.

DHA Required for Optimal Brain Function

The Omega-3 fat DHA continues to gain importance for its ability to rejuvenate brain cells and prevent cognitive decline. Not only is this essential fat required for neuronal and synaptic connections, but research also confirms that it actually controls the genetics that power the development of neural stem cells. Research published in the journal Neuroscience details how DHA helps to maintain brain plasticity and can prevent the decline that often leads to vascular dementia and Alzheimer`s disease.

Too many people take brain health for granted and accept a steady decline in memory and learning to be normal and acceptable. While the brain remains well protected, it`s still susceptible to many of the ravages brought about by poor diet, stress and the environment. Natural nutrients including carnitine, curcumin and DHA are shown to prevent cognitive decline, improve memory and ensure vibrant brain health through advancing age. ... ealth.html

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PostPosted: Thu Dec 16, 2010 10:51 am 
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Compound Derived from Curry Spice Is Neuroprotective Against Stroke and Traumatic Brain Injury

ScienceDaily (Dec. 14, 2010) — A synthetic derivative of the curry spice turmeric, made by scientists at the Salk Institute for Biological Studies, dramatically improves the behavioral and molecular deficits seen in animal models of ischemic stroke and traumatic brain injury (TBI). Two new studies suggest that the novel compound may have clinical promise for these conditions, which currently lack good therapies.

Ischemic stroke is the leading cause of disability and the third leading cause of death of older people in the United States, while TBI is the leading cause of death and disability in both civilians and military personnel under the age of 45; in particular, it is the major cause of disability in veterans returning from Iraq and Afghanistan. In both conditions, those who survive frequently have serious behavioral and memory deficits. The only FDA-approved treatment for stroke is tissue plasminogen activator (TPA), which is effective only in about 20 percent of cases. There is no clinically documented treatment for TBI.

In earlier studies, David R. Schubert. Ph.D., and Pamela Maher, Ph.D., in the Salk Cellular Neurobiology Laboratory had developed a series of new compounds using a novel drug discovery paradigm that starts with natural products derived from plants; it then calls for selecting synthetic derivatives that show efficacy in multiple assays testing protection against various aspects of the nerve cell damage and death that occur in brain injuries and in age-associated neurodegenerative diseases. One compound, called CNB-001, which was derived from curcumin, the active ingredient in the spice turmeric, proved highly neuroprotective in all of the assays; it also enhanced memory in normal animals.

While the Salk group has a great deal of expertise in age-associated neurological diseases such as Alzheimer's, they do not run animal models of TBI and stroke. "To test the prediction that drugs from our new drug discovery scheme will work in multiple models of CNS disease and trauma," Schubert explains, "we undertook a series of experiments to assay the drugs in collaboration with researchers at Cedars-Sinai and UCLA, who are leaders in the fields of stroke and TBI, respectively, and appreciate the potential for therapeutics based on natural products and their derivatives."

Employing the same animal model of stroke that was used to develop TPA, Paul Lapchak, Ph.D., of the Department of Neurology at the Burns and Allen Research Institute at Cedars-Sinai Medical Center in Los Angeles, collaborated with Schubert's team in a study that showed that CNB-001 was at least as effective as TPA in preventing the behavioral deficits caused by stroke. The study, published in the Dec. 2, 2010 edition of the Journal of Neurochemistry, also demonstrated that unlike TPA, which reduces clotting in the blood vessels of the brain, the Salk compound has a direct protective effect on nerve cells within the brain. Maher has found that it maintains specific cell signaling pathways required for nerve cell survival.

Similarly, in a study to be published in early 2011 in Neurorehabilitation and Neural Repair, Fernando Gomez-Pinilla, Ph.D., and his colleagues in the Department of Physiological Science and Division of Neurosurgery at the University of California, Los Angeles used a rodent model of TBI to demonstrate that CNB-001 dramatically reversed the behavioral deficits in both locomotion and memory that accompany the brain injury. As with stroke, CNB-001 was again found to maintain the critical signaling pathways required for nerve cell survival, as well as the connections between nerve cells that are lost with the injury.

The results of these two studies, which used two distinct models of brain injury, indicate that the Salk compound has clinical potential in conditions where there is currently no effective treatment.

"Existing drug therapies for complex neurological conditions such as stroke and Alzheimer's disease target only one aspect of the condition, while in fact many different factors contribute to the pathology," observes Schubert. "In the drug discovery program our lab uses at Salk, drug candidates must show efficacy in tissue culture models of several aspects of the condition before they are introduced into animal models. We believe that this approach is making an important difference in the discovery of effective drugs."

In related work, Maher used the same drug discovery paradigm to identify a compound that is effective in animal models of Huntington's disease. "Although these brain disorders appear very different, they share common changes in the nerve cells, which suggests that compounds that prevent these changes will be effective in multiple disorders," she notes. ... 092254.htm

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PostPosted: Thu Jan 13, 2011 11:09 am 
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NSAID Pain Relievers Raise Heart Risks

Jan. 12, 2011 -- A new study weighs in on the debate over the relative safety of nonsteroidal anti-inflammatory medications (NSAIDs), commonly used to treat joint and muscle aches and pain.

The study, published online in the BMJ, concludes that NSAIDs significantly increase the risk of cardiovascular events in patients who take them regularly.

“These drugs have some use in the treatment of chronic pain,” says Peter Jüni, MD, head of the division of clinical epidemiology at The University of Bern in Switzerland. “But they have safety issues. In the signals we saw, there was a two- to fourfold increase in the risk of myocardial infarctions [heart attacks], stroke, or cardiovascular death, and these are, clinically, considerable increases in risk.”

For example, Jüni says his review found that only 25 to 50 patients would need to be treated with NSAIDs for one year to cause one additional event such as a heart attack or stroke.

Given that millions of people take these drugs, and that many of them are seniors -- members of a group already likely to have other risk factors for heart disease -- that relatively small number needed to harm, as epidemiologists call it, is alarming to doctors.

“There’s a very large overlap between cardiovascular risk and the musculoskeletal symptoms that people take NSAIDs for,” says Wayne A. Ray, PhD, director of the division of pharmacoepidemiology in the department of preventive medicine at Vanderbilt University in Nashville.

A 2002 analysis of the government’s National Health and Nutrition Examination Survey, for example, found that 40% of adults with osteoarthritis, or OA, also had high blood pressure, while 32% percent had high total cholesterol. Twenty percent of people with OA reported that they smoked.

“You have an 80-year-old person with a history of heart disease who has a problem with her knees. This is someone who’s at cardiovascular risk and likely to be taking NSAIDs,” says Wayne, who wrote an editorial that accompanied the study.

Many doctors already exercise caution when considering NSAIDs for the relief of chronic pain because these drugs are also known to increase the risk of ulcers and serious bleeding in the stomach and gastrointestinal tract.

It wasn’t until relatively recently, after a study found that the painkiller Vioxx was associated with significant increases in the risks of heart attacks and strokes, that doctors started to wonder if other drugs in this class might have heart risks, too. Vioxx was taken off the market in 2004.

“We found, almost inadvertently, that these drugs can have cardiovascular effects. We were sort of caught without sufficient knowledge base to guide clinical practices,” Ray says.

“There are differences in the various NSAIDs and these differences might well confer differences in cardiovascular risk. We really have less information than we need about the comparative safety of these drugs,” he says. ... ular-risks

[comment - shows that those who seek NSAID to avoid steriods still face risks]

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PostPosted: Fri Jan 14, 2011 7:36 am 
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NSAID painkillers linked to increased heart risk

Taking certain painkillers daily for some years carries a small increased risk of heart attack and stroke, research has suggested.

The findings relate to non-steroidal anti-inflammatory drugs like ibuprofen prescribed long-term to treat painful conditions such as arthritis.

People taking them now and again are at minimal risk, say experts.

The report, published in the British Medical Journal, looked at more than 100,000 patients in 31 clinical trials.

A Swiss team analysed data from existing large-scale studies comparing use of non-steroidal anti-inflammatory drugs (NSAIDs) - naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib, rofecoxib and lumiracoxib - with other drugs or placebo.

One of the drugs - rofecoxib (also known by its brand name, Vioxx) was withdrawn in 2004 when other studies found a raised risk of heart attacks.

Most of the patients were elderly, with conditions like osteoarthritis, and were taking high doses of NSAIDs daily for at least a year.

The researchers found the medicine increased the risk of death from stroke or heart attack by between two and four times, compared with placebo.

Peter Juni, professor of clinical epidemiology at the University of Bern, Switzerland, told the BBC: "For elderly (people) with musculoskeletal pain there must be extreme care when prescribing or taking these drugs."

But he stressed that the findings did not relate to people taking anti-inflammatories now and again for symptoms such as period pain or sports injuries.

Commenting on the research, the British Heart Foundation said anyone worried about their medication should speak to their doctor.

Medical director Professor Peter Weissberg said: "This confirms what has been known for some years now - taking non-steroidal, anti-inflammatory drugs on a regular basis increases heart attack or stroke risk.

"However, some patients with debilitating joint pains may consider the small increased risk worthwhile when set against the improvement in their quality of life that these drugs bring.

"Anyone who needs regular painkillers should talk to their doctor about which drug is the most appropriate for them. There is lots than can be done to mitigate any potential risks."

These comments were echoed by Simon Maxwell, Professor of Clinical Pharmacology at the University of Edinburgh.

Professor Maxwell said: "The advice to the public should continue to be to take this class of drugs only when they are genuinely necessary to control pain and in the lowest effective dose, not only because of any cardiovascular risk but also because of potential effects on the stomach."

A spokeswoman for the Medicines and Healthcare products Regulatory Agency (MHRA) said patients should not be alarmed about the results from the study.

"Any patients with questions about their current anti-inflammatory treatment should speak to their pharmacist, doctor or nurse at their next routine appointment," she said.

"Traditional NSAIDs and the newer COX-2 inhibitors are extremely important medicines to treat arthritis and other painful conditions, and for most patients the risks of side effects are outweighed by the benefits."

Annual review

COX-2 inhibitors are a new generation of NSAID drugs, which include celecoxib and rofecoxib.

Medical director of Arthritis Research UK Professor Alan Silman said: "Far fewer GPs are now prescribing NSAIDs and COX-2 to their arthritis patients, particularly those with cardio-vascular problems, because of the potential risks, yet for many people who are not at high risk of heart attacks and strokes they remain a highly effective means of combating pain.

"We would advise people with arthritis to seek an annual review of their painkillers with the GP so their risk of cardio-vascular risk can be regularly checked, and so that they can seek advice about alternatives to NSAIDs."

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PostPosted: Sun Feb 06, 2011 7:36 am 
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Newsweek goes insane, says antioxidants bad for health

(NaturalNews) Just when you think you've heard it all, a major mainstream media source goes off the deep end and says that natural antioxidants can kill you. Yes, you heard that right. Citing a few sketchy studies that contradict the bulk of published research on the subject, a report in Newsweek, presumably intended to be taken seriously, actually alleges that the antioxidants found naturally in fruits, vegetables, and various superfoods, are dangerous to your health. And you just might want to stop taking them, the report humorously states.

Of course, the idea that natural antioxidants are harmful to health is complete nonsense, as countless studies have shown they boost immunity, prevent oxidative damage, protect against the negative effects of aging, and generally improve overall health ( Nevertheless, some in the mainstream media seem hellbent on slandering the very nutritional components that give us life, while remaining largely silent about the numerous detriments brought about by conventional medical interventions like pharmaceutical drugs.

The Newsweek piece quotes a British "chemist and science writer" named David Bradley as saying that "oxidizing agents," also known as free radicals, are a "front-line of immune defense against pathogens and cancer cells." He goes on to claim that because antioxidants eliminate these free radicals, they are damaging to health.

But the foundational science behind both antioxidants and the oxidative agents they target completely contradicts Bradley's unfounded statement. Oxidative stress causes the body's cells to become damaged, and this cell damage leads to a host of chronic diseases, not to mention rapid aging and health deterioration. It is the antioxidants that scavenge and root out these damaging offenders and protect the body from harm, not the other way around as the Newsweek piece suggests.

What the report suggests is to eliminate the very components needed by the body to protect against things like heart disease and cancer, in order to protect against heart disease and cancer. It literally makes no sense at all. And urging people to avoid antioxidants based on this flawed hypothesis is nothing more than highly irresponsible conjecture, which is best ignored for the sake of public health. ... dants.html

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PostPosted: Tue Feb 15, 2011 9:35 am 
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Breast Cancer Breakthrough - Cut Your Risk of Death in Half

According to the National Breast Cancer Foundation, 200,000 new cases of breast cancer will be diagnosed each year in the US, making it three times more common than other gynecological cancers.

Breast cancer will claim the lives of 40,000 people this year.

What is really disturbing is the speed at which breast cancer rates have risen over the past 5 decades. In 1960, one in twenty women were diagnosed—but today, it is one in seven.

The following are some important facts about this type of cancer:

One woman in eight who lives to age 85 will develop breast cancer.

Breast cancer is the leading cause of death for women age 40 to 55.

Fifteen percent of all breast cancers occur in women under age 45; in this age group, breast cancers are more aggressive and have lower recovery rates.

Eighty percent of breast lumps are NON-cancerous.

Seventy percent of breast cancers are found through breast self-exams.

About 80 percent of women diagnosed with breast cancer have no family history of breast cancer.

Unfortunately, the current medical paradigm is relatively clueless about what causes breast cancer and how to effectively treat it. Most conventional cancer treatments actually add insult to injury by doing more harm than good—a fact that up to this point has been swept under the rug by the medical industry.

Fortunately, we're beginning to see the initial stirrings of change, as you will see from the latest research I'll be presenting later.

In the largest review of research into lifestyle and breast cancer, the American Institute of Cancer Research estimated that about 40 percent of U.S. breast cancer cases could be prevented if people make wiser lifestyle choices. I believe these estimates are seriously LOW, and it is more likely that 75 to 90 percent of breast cancers could be avoided by strictly applying the recommendations I will review below.

In fact, the latest paleoanthropological research shows that cancer was virtually nonexistent in humans before poor diet and pollution appeared, finally proving that cancer is a man-made disease.

My aim for this article is to provide you with a broad understanding of the factors that lead to the development of this deadly disease—as we now understand them—and what you can do preventatively to avoid becoming the next victim..If you happen to be a man, please read on since it actually does apply to you as well.

Men are NOT Immune to Breast Cancer

Breast cancer is not a disease exclusive to women. For every 100 women with breast cancer, one man will develop the disease. The National Breast Cancer Foundation estimates approximately 1,700 men will develop breast cancer and 450 will die from it each year.

The average age men are diagnosed with breast cancer is 67, versus 62 for women, meaning male cancers are often caught in a more advanced stage. If you work around petrochemicals, your risk is much higher. Men who work around gasoline and combustion products have a significantly higher risk of developing breast cancer.

Males and their doctors may be diverted from an accurate diagnosis due to enlargement of the breasts or gynecomastia, a common and benign condition, plus the fact that men are generally less vigilant about checking for breast lumps.

Types of Breast Cancer

Breast cancer is classified into two types, based on whether or not it is invasive:

Noninvasive (in situ) breast cancer: Cancer cells have not spread to adjacent areas of your breast—they have remained in their place of origin. The most common type is ductal carcinoma in situ (DCIS), which occurs in the lining of the milk ducts. Noninvasive breast cancer is sometimes called "stage 0" cancer.
Invasive breast cancer. Cancer cells infiltrate or spread outside the membrane that lines a duct or lobule, into surrounding tissues. The cancer cells can then travel to other parts of your body. Invasive breast cancer can be stage I, II, III, or IV, depending on how advanced it is.
Breast cancer can be further classified according to what type of tissue it arises from:

- Milk ducts: Ductal carcinoma is the most common type of breast cancer.
- Milk-producing lobules: Lobular carcinoma originates in the lobules, where breast milk is produced.
- Connective tissues (muscles, fat and blood vessels): Rarely, breast cancer can originate from these breast tissues; in this case, it's called sarcoma

Inflammatory Breast Cancer: The Rarest and Most Aggressive Form

Inflammatory breast cancer (IBC) is a rare form of breast cancer of sudden onset (weeks to months) and can easily be confused with a breast infection (mastitis). The affected breast is red, swollen, warm and tender because cancer cells have blocked the lymphatic vessels in your breast.

You might or might not have a lump.

IBC accounts for between 1 and 5 percent of all breast cancer cases in the U.S., and is more common among younger women and African American women. There have been some cases documented in men. IBC is the most aggressive form of breast cancer, and survival rates are worse than for other types of breast cancer.

You should seek medical attention immediately if you have the above symptoms—or if you are being treated for mastitis but your symptoms are not resolving as expected.

Signs and Symptoms to Watch For

The most common signs and symptoms of breast cancer include the following:

- A breast lump or thickening that feels different from the surrounding tissue
- Bloody discharge, or other unusual discharge, from your nipple
- A change in your breast's size or shape
- Changes in the skin on your breast, such as dimpling or indentation
- Redness or pitting of your breast skin—kind of like the skin of an orange
- Pain or tenderness in your breast
- An inverted nipple
- Peeling or flaking of the nipple
- Enlarged lymph nodes or swelling in your armpit

If you have any of these changes, you should consult your healthcare provider immediately. But don't panic—remember, the majority of breast tumors are benign. Many of the above signs can indicate other issues besides cancer, and your healthcare provider can help you sort it out.

What Causes Breast Cancer?

We now know that breast inflammation is KEY to the development and progression of breast cancer. Inflammation is not the cause, but rather is a key process that sets the stage for breast cancer to occur. There are certainly many aggravating factors, from foods to chemicals in the environment to lifestyle patterns and genetics—but it is the INFLAMMATION that these things cause that starts the wheel turning.

Scientists have shown that an inflammatory process within the breast itself promotes growth of breast cancer stem cells. That's the bad news.

The good news?

Researchers were able to inactivate this inflammation selectively, which reduced the activity of these stem cells and stopped breast cancer from forming. Although your genes are a factor in your breast cancer risk, it is not your genes that dictate your health but rather the expression of them, and that depends on what genes you "turn on and off" with your lifestyle and emotional state (epigenetic factors).

In other words, you have more power over your health than your genetics does!

Breast Cancer is Closely Tied to Estrogen Exposure

There are a number of studies that have given us clues about the factors contributing to breast cancer. But one of the most significant factors is synthetic hormone replacement therapy (HRT). According to a study published online in the Journal of the National Cancer Institute, breast cancer rates for women dropped in tandem with decreased use of HRT. In Canada, between 2002 and 2004, HRT use dropped by 7.8 percent. During that same time, breast cancer rates also fell by 9.6 percent.

This further supports existing evidence that HRT is linked with breast cancer, which is an estrogen-related cancer. So it is no surprise that giving women potent synthetic estrogens will increase their risk.

However, there's a twist.

After remaining stable at around five percent between 2004 and 2006, breast cancer rates then began to rise again, even though HRT use remained low. The researchers claim this is an indication that HRT simply speeds up tumor growth, as opposed to directly causing it.

It's also important to remember that you are exposed to a large number of estrogen-like compounds daily, called xenoestrogens. Estrogen pollution is increasingly present all around you, from plastics to canned food and drinks, food additives, household cleaning products, and pesticides. And estrogen levels are rising in our waterways as a result of the runoff from factory animal farms.

Still, whether it's a promoter or a causative factor, there's good reason to be wary of using HRT to address natural menopause. There is no reason to subject yourself to synthetic hormones when you reach menopause—the risk is simply too great.

If you are experiencing excessive menopausal symptoms, you may want to consider bioidentical hormone replacement therapy, which uses hormones that are molecularly identical to the ones your body produces and does not wreak havoc on your system, which is a much safer alternative.

There are similar risks for younger women who use oral contraceptives—birth control pills, which are also comprised of synthetic hormones—have been linked to cervical and breast cancers. Another aggravating factor in breast cancer is, unfortunately, the breast cancer screening tool itself.

Are Mammograms Fueling Breast Cancer Rates?

Mammography is a great example of a stubborn head-in-the-sand approach to cancer screening. Americans are already exposed toseven times more radiation from diagnostic scans than they were in 1980. It is well known that ionizing radiation increases the cellular mutations that lead to cancer—and mammograms aim a highly focused dose directly at your breasts, thereby increasing your cancer risk!

WHY would you want to do this?

Mammograms expose your body to radiation that can be 1,000 times greater than a chest x-ray, which we know poses a cancer risk. Mammography also compresses your breasts tightly, and often painfully, which could lead to a lethal spread of cancerous cells, should they exist. Dr. Charles B. Simone, a former clinical associate in immunology and pharmacology at the National Cancer Institute, said:

"Mammograms increase the risk for developing breast cancer and raise the risk of spreading or metastasizing an existing growth."

Others have spoken out against mammography. Dr. Samuel Epstein, a top cancer expert who has been warning people for years about the dangers of mammography, explains:

"The premenopausal breast is highly sensitive to radiation, each 1 rad exposure increasing breast cancer risk by about 1 percent, with a cumulative 10 percent increased risk for each breast over a decade's screening..."

"The high sensitivity of the breast, especially in young women, to radiation-induced cancer was known by 1970. Nevertheless, the establishment then screened some 300,000 women with X-ray dosages so high as to increase breast cancer risk by up to 20 percent in women aged 40 to 50 who were mammogramed annually."

In July 1995, an article in The Lancet about mammograms read:

"The benefit is marginal, the harm caused is substantial, and the costs incurred are enormous."

There is no solid evidence that mammograms save lives, in spite of the propaganda some organizations constantly parrot to the press. Mammograms are often touted as a "life-saving" form of cancer screening, responsible for reducing breast cancer death rates by 15 to 25 percent. But this reported benefit is based on outdated studies done decades ago.

In September 2010, the New England Journal of Medicine, one of the most prestigious medical journals, published the first recentstudy in years to look at the effectiveness of mammograms, and their findings are a far cry from what most public health officials and physicians would have you believe.

Their bottom line was that mammograms might have only reduced cancer death rates by 0.4 deaths per 1,000 women—an amount so small it may as well be zero. Put another way, 2,500 women would have to be screened over 10 years for a single breast cancer death to be avoided.

So, not only are mammograms unsafe, but they are NOT saving lives as many professionals believed they were.

Past research has also demonstrated that adding an annual mammogram to a careful physical examination of the breasts does not improve breast cancer survival rates over a physical examination alone.

False Positives are Alarmingly Common in Mammography

Another glaring problem with mammography is its unacceptably high rate of false positives. If a mammogram detects an abnormal spot in a woman's breast, the next step is typically a biopsy. This involves taking a small amount of tissue from the breast, which is then looked at by a pathologist under a microscope to determine if cancer is present. Estimates are that 17 percent of DCIS cases found through needle biopsy are misdiagnosed.

Mammograms carry a first-time false positive rate of up to 6 percent.

The problem is that early stage cancer like DCIS can be very hard to diagnose, and pathologists have a wide range of experience and expertise. There are no diagnostic standards for DCIS, and there are no requirements that the pathologists doing the readings have specialized expertise.

Dr. Shahla Masood, the head of pathology at the University of Florida College of Medicine in Jacksonville, told the New York Times:

"There are studies that show that diagnosing these borderline breast lesions occasionally comes down to the flip of a coin."

Unnecessary Mastectomies are More Common than You Might Think

False positives can lead to unnecessary emotional stress and expensive repeat screenings, exposing you to even more radiation, chemotherapy, and unnecessary invasive procedures including biopsies and major surgery. Women have actually undergoneunnecessary mastectomies after receiving a false positive mammogram report.

After receiving a breast cancer diagnosis, most women are afraid and even frantic to do whatever it takes, as soon as possible, to fight and remove the cancer. And usually, that involves the "slash and burn" approach. Can you imagine what it would be like to go through surgery, having one or both of your breasts removed along with receiving debilitating radiation treatments and toxic drugs, only to later be told that you never had cancer?

This scenario happens more often than you might think; you can read about several women's terrifying ordeals with false breast cancer diagnoses here.

And there is new evidence that breast cancer might go away on its own a fair amount of the time. Yes—WITHOUT intervention. A group of researchers who track breast cancer rates found evidence to suggest that some tumors found by mammograms might naturally disappear on their own.

Mammograms will not prevent you from getting breast cancer, and the latest study shows they offer very little benefit in improving your chances of survival. Effective cancer screening methods are important, but mammography is simply NOT the answer.

But then, what is the answer?

The screening tool I recommend is breast thermography.

Thermography: Cancer's Best Kept Secret

By measuring the radiation of infrared heat from your body, thermographic screening can detect signs of breast cancer as much as 10 years earlier than either mammography or a physical exam—all without any ionizing radiation or mechanical pressure.

And thermography has NO damaging side effects.

Thermographic breast screening is able to predict the likelihood of breast cancer, before any tumors have formed, because it provides a snapshot of the early stages of angiogenesis—the formation of a direct supply of blood to cancer cells, which is a necessary step before they can grow into sizeable tumors.

This is the classic use of "preventative medicine" because you can detect negative changes before you develop the disease—while you still have time to turn things around.

Annual thermograms allow you to map changes in your body's heat patterns over time. If you would like to learn more about thermography, I invite you to download my FREE thermography report.

What About Breast Self-Exams?

Breast self-exams have long been recommended as a simple way for women to keep track of anything unusual in their breasts. Now, after studies have found that such exams do not reduce breast cancer death rates and actually increase the rate of unnecessary biopsies, many experts are recommending a more relaxed approach known as "breast awareness."

Breast awareness is really self-explanatory. It means you should regularly check your breasts for changes, but can do so in a way that feels natural to you. In other words, you don't have to do it on the same day each month, or using any particular pattern.

Simply be aware of what's normal for you so you can recognize anything out of the ordinary. Although breast cancer is much less common in men, it certainly wouldn't hurt for men to practice "breast awareness" as well.

One of the BEST Supplements for Breast Cancers

Dr. William LaValley from Austin Texas, is one of the top natural medicine cancer physicians I know and he recently shared this important information on curcumin which has the most evidence based literature for as a cancer support than any other nutrient. There are over 100 different pathways that curcumin has an effect on once it gets into the cell. Interestingly this also includes the metabolite of curcumin and its derivatives which are also anti-cancer. Curcumin appears to be safe in the treatment of all cancers.

In India where turmeric is widely used, the prevalence of four common U.S. cancers -- colon, breast, prostate and lung -- is 10 times lower. In fact, prostate cancer, which is the most frequently diagnosed cancer in U.S. men, is rare in India and this is attributed, in part, to the curcumin in turmeric.

Numerous studies have looked into this potential cancer-fighting link, with promising results. For instance, curcumin has been found to:

- Inhibit the proliferation of tumor cells
- Inhibit the transformation of cells from normal to tumor
- Help your body destroy mutated cancer cells so they cannot spread throughout your body
- Decrease inflammation
- Enhance liver function
- Inhibit the synthesis of a protein thought to be instrumental in tumor formation
- Prevent the development of additional blood supply necessary for cancer cell growth

And according to researchers from the University of Texas M.D. Anderson Cancer Center, curcumin blocks a key biological pathway needed for development of melanoma and other cancers.

The spice actually stops laboratory strains of melanoma from proliferating and pushes the cancer cells to commit suicide by shutting down nuclear factor-kappa B (NF-kB), a powerful protein known to induce abnormal inflammatory response that leads to an assortment of disorders such as arthritis and cancer.

To get the full benefits that curcumin has to offer, you will want to look for a turmeric extract with at least 95% curcuminoids that contains only 100% certified organic ingredients.

The formula should be free of fillers, additives and excipients (a substance added to the supplement as a processing or stability aid), and the manufacturer should use safe production practices at all stages: planting, cultivation, selective harvesting, and then producing and packaging the final product.

Details on How to Use Curcumin

The unfortunate challenge as this time is that there are not really any very good formulations of curcumin available to use in cancer. This is because relatively high doses are required and curcumin is not absorbed that well. Typical anticancer doses are up to three grams of good bioavailable curcmin extract, three to four times daily.

One work around for this is to use the curcumin powder and make a microemulsion of it by combining a tablespoon of the powder and mixing it into 1-2 egg yolks and a teaspoon or two of melted coconut oil. Then using a high speed hand blender to emulsify the powder.

Another strategy you can use to increase absorption is to put one tablespoon of the curcumin powder into a quart of boiling water. It must be boiling when you add the powder as it will not work as well if you put it in room temperature water and heat the water and curcumin. After boiling it for ten minutes you will have created a 12% solution and you can drink this once it has cooled down. The curcumin will gradually fall out of solution over time and in about six hours it will be a 6% solution so it is best to drink the water within four hours. It does have a woody taste.

One caution to know is that you want to avoid the "yellow kitchen" syndrome. Curcumin is a very potent yellow pigment and can permanently discolor surfaces if you aren't careful. So you can perform the mixing under the hood of your stove with the blower on to make sure no powder gets into your kitchen.

Keeping Abreast of the Research

I mentioned earlier that we are beginning to see the stirrings of change. Let me clarify what I meant by that. New scientific research on old methodologies is challenging some of the long-held notions about conventional cancer treatments, and some of this research is making it into mainstream medical journals.

Cancer screening is finally getting some long-awaited scrutiny, as it should be. And that process has found some of the conventional breast cancer treatment methods to be significantly flawed and in need of revision. It's about time!

Here are some of the more significant recent findings related to conventional breast cancer treatment:

Needle biopsies

Needle biopsies are widely used as part of the traditional allopathic approach to diagnosing breast cancer. But they may accidentally cause malignant cells to break away from a tumor, allowing it to spread to other areas of your body.

According to a study from the John Wayne Cancer Institute, it appears that a needle biopsy may increase the spread of cancer by 50 percent compared to patients who receive excisional biopsies, also known as lumpectomies.


A 2010 study found, for certain women, a lumpectomy might not be necessary. The procedure was found to not prolong survival or prevent recurrence of breast cancer.

Lymph Node Removal

Lymph node removal might not be necessary after all. Today, the standard treatment for breast cancer patients whose cancer has spread to the sentinel lymph node is to surgically remove the other nodes as well—a procedure called axillary node dissection. (The "sentinel node" refers to the node closest to the tumor, or the lymph node that can be reached by metastasizing cancer cells first.)

However, according to this latest study, lymph node removal has virtually no impact on survival or disease recurrence, while it causes additional pain and debilitation. After five years, 82.2 percent of the women who had the axillary nodes removed were still alive and in remission, compared to 83.8 percent of the women who did not get the operation.

And, interestingly enough, the cancer recurrence was actually slightly higher in the group who had the operation, compared to those who didn't.

Chemotherapy and Radiation

In addition to the removal of lymph nodes, current conventional treatment also typically includes chemotherapy and radiation therapy.
Chemo is a standard recommendation for women whose cancer has spread to their lymph nodes, despite its magnificent failure rate and oftentimes lethal side effects. One study concluded that as many as 18,000 of the 45,000 women each year who undergo chemo for breast cancer could safely skip it.

Similarly, six or more weeks of radiation are also part of the standard treatment for most women with breast cancer. However, according to another recent study, just ONE dose of radiation, delivered with precision to the affected site directly after her lumpectomy, had the same rate of effectiveness as the extended radiation treatment.

Breast Cancer Prevention Musts

A healthful diet, regular physical exercise, appropriate sun exposure or oral supplements to optimize your vitamin D levels, and aneffective means of managing your emotional health are the cornerstones of just about any cancer prevention program, including breast cancer.

Regular physical activity has been shown to decrease the likelihood of developing breast cancer, as well as decreasing your chances of dying from it by 50 percent, once diagnosed.

It is also important to watch out for excessive iron levels. Elevated iron is actually quite common once women stop menstruating. The extra iron works as a powerful oxidant, increasing free radicals in your body and thereby increasing your risk of cancer.

The best way to monitor your iron is to have your ferritin level drawn. Ferritin is the iron transport protein and should not be above 80. If yours is elevated, you can reduce it simply by donating your blood.

The following lifestyle strategies will help you to further lower your breast cancer risk:

Optimize your vitamin D. Vitamin D influences virtually every cell in your body and is one of nature's most potent cancer fighters. This is one of the most important steps you can take to protect yourself from cancer.

Vitamin D is actually able to enter cancer cells and trigger apoptosis (cell death). When JoEllen Welsh, a researcher with the State University of New York at Albany, injected a potent form of vitamin D into human breast cancer cells, half of them shriveled up and died within days! The vitamin D worked as well at killing cancer cells as the toxic breast cancer drug Tamoxifen, without any of the detrimental side effects and at a tiny fraction of the cost.

If you have cancer, your vitamin D level should be between 70 and 100 ng/ml. Vitamin D works synergistically with every cancer treatment I'm aware of, with no adverse effects.

I invite you to watch my one-hour free lecture on vitamin D to find out what your optimal vitamin D levels should be and how to optimize them.

Get plenty of natural vitamin A. There is evidence that vitamin A also plays a roll in preventing breast cancer. It's best to obtain it from vitamin A rich foods, rather than a supplement. Your best sources are organic egg yolks, raw butter, raw whole milk, and beef or chicken liver.

However, beware of supplementing as there's some evidence that vitamin A can negate the benefits of vitamin D. Since appropriate vitamin D levels are crucial for your health in general, not to mention cancer prevention, this means that it's essential to have the proper ratio of vitamin D to vitamin A in your body.

Ideally, you'll want to provide all the vitamin A and vitamin D substrate your body needs in such a way that your body can regulate both systems naturally. This is best done by eating colorful vegetables (for vitamin A) and by exposing your skin to sun every day (for vitamin D).

Avoid charring your meats. Charcoal or flame broiled meat is linked with increased breast cancer risk. Acrylamide—a carcinogen created when starchy foods are baked, roasted or fried—has been found to increase breast cancer risk as well.

Avoid unfermented soy products. Unfermented soy is high in plant estrogens, or phytoestrogens, also known as isoflavones. In some studies, soy appears to work in concert with human estrogen to increase breast cell proliferation, which increases the chances for mutations and cancerous cells.

Improve Your Insulin Receptor Sensitivity. The best way to do this is with exercise and a diet comprised of foods appropriate for your nutritional type.

Maintain a healthy body weight. This will come naturally when you begin eating right for your nutritional type and exercising. It's important to lose excess body fat because fat produces estrogen.

- Drink a quart of organic green vegetable juice daily. Please review my juicing instructions for more detailed information
- Get plenty of high quality animal-based omega-3 fats, such as krill oil. Omega-3 deficiency is a common underlying factor for cancer.

Curcumin. This is the active ingredient in turmeric and in high concentrations can be very useful in the treatment of breast cancer. Concern must be addressed with the solubility though as it is not well absorbed. However it does show great therapeutic potential in preventing breast cancer metastasis.

Avoid drinking alcohol, or at least limit your alcoholic drinks to one per day.

Breastfeed exclusively for up to six months. Research shows this will reduce your breast cancer risk.

Avoid wearing underwire bras. There is a good deal of data that metal underwire bras increase your breast cancer risk.

Avoid electromagnetic fields as much as possible. Even electric blankets can increase your cancer risk.

Other Research-Based "Dos and Don'ts"

The following is a list of various factors that have been scientifically found to impact breast cancer in one way or another. Many are isolated studies that offer food for thought and open up potential avenues for future research. For more information on each, simply click on the links provided.

Depression can influence breast cancer survival. Women whose depression lifts in the first year after being told they have advanced breast cancer outlive by more than two years those whose depression symptoms worsened.

SSRIs (a category of antidepressant drug) are associated with increased breast cancer risk.

CoQ10 ... 10/Patient appears to be another useful tool. Ubiquinol would be the preferred form as it works better than the oxidized CoQ10.

Black cohosh shows promise in fighting breast cancer by inducing apoptosis in human breast cancer cells.

Artemisinin (a compound in wormwood) has been shown to be toxic to human breast cancer cells.

A high carbohydrate diet may increase your breast cancer risk.
Foods that have a scientific basis for fighting breast cancer include kelp, spicy foods, cruciferous vegetables (especially broccoli), and evening primrose oil.

Three cups of tea daily may slash your breast cancer risk by 50 percent.

If you eat a poor diet, it can cause DNA changes that may increase your daughters' and granddaughters' risk of breast cancer. ... 10718.html

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Antioxidant drugs may aid in cancer treatment

Drugs that provide a dose of antioxidants, such as those used to treat malaria and diabetes, might also help treat cancer, a new study suggests.

The results show a process known as oxidative stress, which damages cells, can fuel tumor growth. Specifically, oxidative stress triggers cells near the cancer to release nutrients, which feed the cancer cells.

Brain Development May Start With Surprisingly Bad Wiring Teens' Best Friend? Kids with Dogs Exercise More Heart Scan Radiation Linked to Small Rise in Cancer Risk US Loses Its Fat Supremacy "Cancer cells are parasites, and the way they do their business is that they use oxidative stress as a weapon to extract nutrients from adjacent normal cells," said study researcher Dr. Michael Lisanti, professor of cancer biology at Jefferson Medical College in Philadelphia.

Because antioxidant drugs ameliorate oxidative stress, they might be useful tools for fighting cancer, the researchers said.

"The oxidative stress is part of a process to make food for cancer," Lisanti said. "So the best way to then kill a cancer would be to cut off the oxidative stress."

Current cancer treatments do not use antioxidant drugs, because it is thought these drugs might interfere with chemotherapy. Some chemotherapies are thought to work in part by increasing oxidative stress on the cancer cells. "We should rethink the idea of using antioxidants" during chemotherapy, Lisanti said.

However, the new study was conducted on cells in a lab dish, not on tumors in people. And clinical trials are needed to see whether antioxidant drugs, such as the diabetes drug metformin or the malaria drug chloroquine, could benefit those with cancer, Lisanti said. But the ways these drugs reduce oxidative stress make them promising cancer treatments, he said.

Antioxidants and cancer

Previous research has suggested that oxidative stress may promote cancer, but researchers weren't sure exactly how this worked.

Lisanti and his colleagues had previously found that the presence of a protein known as Caveolin-1 is strongly tied to the survival of breast cancer patients. Patients with an aggressive form of breast cancer who had this protein in certain cells had a survival rate of 75 percent over 12 years. But among patients who did not have Caveolin-1 in their cells, the survival rate was less than 10 percent after five years.

Caveolin-1 prevents oxidative stress in cells that surround the cancer, called fibroblasts, the researchers said.

In the new study, the researchers removed the Caveolin-1 protein from these fibroblasts, and the size of the neighboring tumors increased four-fold.

The researchers said the loss of Caveolin-1 in the fibroblasts increased the oxidative stress on the fibroblasts, causing them to degrade and leak nutrients, which fed the cancer cells.

And further, when the researchers inserted a gene to get the fibroblasts to make a different antioxidant protein, they found that it stopped fibroblasts from leaking nutrients, Lisanti said.

This provides genetic evidence that antioxidants could be used to treat cancer, Lisanti told MyHealthNewsDaily.

Proving the benefits

To date, evidence of the effects of antioxidants on cancer has been mixed.

For example, a recent study found that women in China who took the antioxidants vitamins E and C during the first six months after they were diagnosed with breast cancer had a reduced risk of death and recurrence of their cancer, compared with women who did not take these vitamins. The link held true regardless of whether the women were on chemotherapy. However, there was no benefit to taking the vitamins if the women were undergoing radiation treatments as well.

Other researchers, writing in the journal Breast Cancer Research and Treatment in 2009, reviewed the findings of 22 previous studies, and concluded that taking antioxidants during chemotherapy, radiation treatments or hormonal therapy for breast cancer did not benefit the patients, but didn't harm them, either.

More clinical trials are needed to determine the short- and long-term effects of consuming antioxidants during cancer treatment, the researchers of that study concluded.

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PostPosted: Sat Feb 19, 2011 7:43 am 
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Terry Fox runs fund cancer research at UAE University
Erin Conroy

AL AIN // The cancer-fighting powers of a popular Indian spice have fascinated scientists around the world for years.

Now a UAE research team is exploring the benefits of incorporating turmeric into chemotherapy, and looking for ways to use it in a potential cancer drug.

The project at UAE University's faculty of medicine and health sciences is partially funded by the Terry Fox Foundation, which organises runs in cities around the world - including yesterday's event in Abu Dhabi - to raise money for cancer research.

A lab run by Dr Sehamuddin Galadari, a professor of biochemistry and molecular cell biology at the university, will receive the final instalment of a Dh300,000 grant this year. The funds will support research on the benefits of turmeric, a shrub that is related to ginger. Ground down, it becomes a warm and peppery kitchen spice.

Turmeric has long been touted as a natural anti-inflammatory and has historically been used in health remedies in India, Indonesia, China, the Philippines and other parts of the world.

"Nature's pharmacy — the nutrients, vitamins and minerals — provides unique opportunities and improves our lives," Dr Galadari said during an interview in his lab. "It's important to remember that there is a synergy between our existence and our environment."

His team has found that curcumin, the major yellow pigment extracted from turmeric, generates enzyme activities that suppress tumors.

In cancer, the normal balance of cell growth and cell death are disrupted, leading to overgrown and damaged cells that can spread to other parts of the body. Some chemotherapy drugs induce apoptosis, or programmed cell death, to stop uncontrolled cell growth.

Dr Galadari, who is also the assistant dean for research and graduate studies at the university, is currently testing curcumin's tendency to slow growth in a variety of malignant cell lines. His previous research, published in the peer-reviewed journal Free Radical Biology & Medicinehas found that the spice could be a prime candidate for developing an anti-cancer drug.

"If the curcumin is switching off the proliferation step but also turning on a pro-death gene, it can encourage death of possible mutated or cancerous cells," he said.

Dr Galadari is also testing the possibility that curcumin might work against other treatments. The research looks at whether the powerful anti-oxidant might protect cancerous cells against stress damage caused by hydrogen peroxide, which is used in some cancer therapies.

The goal, he says, would be to use curcumin with a pharmaceutical drug.

"We must not ignore other drugs, but use them in a combinatory effect: for the curcumin to complement them, or the drugs to complement it," he said.

The project began in 2005. Funding has been critical at a time when money for UAE research is scarce, he said.

"Resources are very limited, so we rely on these much-needed philanthropic contributions for cancer research," he said. "For the sake of our country's contribution to science, the hope is that through this we will also train our young researchers and possibly discover a new drug or treatment."

The UAE's grant-making arm, the National Research Foundation, has not distributed grants it approved since it was founded in 2008, as it awaits budget approval. As a result, some institutions and universities, including UAE University, have taken the initiative to distribute funding.

The curcumin project is partially funded by the Sheikh Hamdan Award for Medical Sciences and the Emirates Foundation, an independent philanthropic organisation.

The Terry Fox Foundation says it has raised close to US$500 million (Dh1.83 billion) worldwide for cancer research. Proceeds are raised in honour of Terry Fox, a young man who, with an articial leg replacing the one he lost to cancer, embarked on a cross-Canada run to raise funds for cancer research. He died of the disease in 1981 before he could complete his journey.

Funds from the foundation's marathons are distributed to scientists in the country of origin, chosen through a competitive peer-review process.

The UAE has become one of the top supporters of the cause outside of Canada, and organisers estimate that about 65,000 people have taken part in Terry Fox events in the country since 1995. ... university

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Discover the super-food power of turmeric

(NaturalNews) Foods that have an incredible array of health benefits that go well beyond just their nutrient value are considered `super-foods.` Turmeric is an herb native to Southeast Asia that is a true super-food shown to have remarkable healing and anti-inflammatory properties that are just now being discovered.

Cellular inflammation is a common day epidemic that is it is the fundamental cause of degenerative disease in our society. Turmeric has been shown to reduce inflammation & oxidative stress as well as any herbal medicinal ever studied.

Turmeric root is extraordinarily rich in curcuminoid polyphenol anti-oxidants that give it a classic yellow-orange color. The principal crucuminoid is curcumin which is responsible for much of the health benefits attributed to turmeric. The other 2 curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin.

Blood sugar imbalances and insulin resistant cell membranes are critical factors that promote inflammatory conditions in the body. Curcumin has been shown to stabilize blood sugar and reverse cellular insulin resistance by increasing the number of insulin receptors and improving the receptor binding capacity to insulin.

Curcumin has been shown to activate PPAR (peroxisome proliferator-activator receptor), which is a group of nuclear receptor proteins that regulate gene expression and modulate sugar uptake and utilization from the blood. Curcumin also acts on the liver to decrease the activity of enzymes that release sugar into the blood while increasing activity of enzymes that store sugar. Through these mechanisms, curcumin has been shown to significantly reduce blood glucose and triglyceride levels in diabetic rats.

When blood sugar imbalances occur without sufficient regulation, glucose cross-links are formed with functional proteins. These new molecules are called Advanced Glycolytic Enzymes (AGE`S) that damage cell membranes, vital enzyme systems, and perpetuate inflammatory conditions in the body. Curcumin has been shown to inhibit the formation of these dangerous substances and turn off the inflammatory fires.

Turmeric is the 4th highest anti-oxidant rich herb with an extraordinarily impressive ORAC score of 159,277. These anti-oxidants such as curcumin are very powerful modulators of oxidative stress.

Turmeric also boosts levels of natural cellular anti-oxidants such as glutathione, superoxide dismutase, and catalase. These molecules are critical for the body to limit oxidative stress all day long. The greater the surplus of cellular anti-oxidants the less stress and damage occurs to vital organ systems.

Turmeric`s powerful curcuminoids have been shown to reduce the inflammatory mediating prostaglandins, cytokines and other molecules such as interleukin-6 & tumor necrosis factor-alpha (TNF-alpha). This tips the scales; it pulls the body out of an inflammatory cascade and promotes anti-inflammatory behavior at the cellular level.

Turmeric`s ability to inhibit oxidative stress, AGE formation, & inflammatory prostaglandins across multiple organ systems and multiple biochemical pathways makes it an incredibly powerful anti-aging and performance enhancing aid. Through the above mentioned mechanisms turmeric has been shown to reverse diabetes and improve blood vessel elasticity.

This stabilizes blood pressure and improves cardiovascular function. Additionally, by inhibiting pro-inflammatory prostaglandins it is a powerful pain inhibitor and cancer cell inhibitor. Turmeric improves blood flow and reduces brain inflammation, thus making you cognitively sharper while protecting against Dementia, Alzheimer`s, Parkinson`s and every other neurodegenerative disorder. It has been shown to speed up wound healing from cuts & burns while reducing inflammatory skin disorders such as psoriasis and eczema. ... rfood.html

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Jefferson researchers provide genetic evidence that antioxidants can help treat cancer

PHILADELPHIA—Researchers from Jefferson's Kimmel Cancer Center have genetic evidence suggesting the antioxidant drugs currently used to treat lung disease, malaria and even the common cold can also help prevent and treat cancers because they fight against mitochondrial oxidative stress—a culprit in driving tumor growth.

For the first time, the researchers show that loss of the tumor suppressor protein Caveolin-1 (Cav-1) induces mitochondrial oxidative stress in the stromal micro-environment, a process that fuels cancer cells in most common types of breast cancer.

"Now we have genetic proof that mitochondrial oxidative stress is important for driving tumor growth," said lead researcher Michael P. Lisanti, M.D., Ph.D., professor of cancer biology at Jefferson Medical College of Thomas Jefferson University and member of the Kimmel Cancer Center at Jefferson. "This means we need to make anti-cancer drugs that specially target this type of oxidative stress. And there are already antioxidant drugs out there on the market as dietary supplements, like N-acetyl cysteine."

These findings were published in the online February 15 issue of Cancer Biology & Therapy.

Lisanti's lab previously discovered Cav-1 as a biomarker that functions as a tumor suppressor and is the single strongest predictor of breast cancer patient outcome. For example, if a woman has triple negative breast cancer and is Cav-1 positive in the stroma, her survival is greater than 75 percent at 12 years, versus less than 10 percent at 5 years if she doesn't have the Cav-1 protein, according to Dr. Lisanti.

The researchers also established Cav-1's role in oxidative stress and tumor growth; however, where that stress originates and its mechanism(s) were unclear.

To determine this, Jefferson researchers applied a genetically tractable model for human cancer associated fibroblasts in this study using a targeted sh-RNA knock-down approach. Without the Cav-1 protein, researchers found that oxidative stress in cancer associated fibroblasts leads to mitochondrial dysfunction in stromal fibroblasts. In this context, oxidative stress and the resulting autophagy (producton of recycled nutrients) in the tumor-microenvironment function as metabolic energy or "food" to "fuel" tumor growth.

The researchers report that the loss of Cav-1 increases mitochondrial oxidative stress in the tumor stroma, increasing both tumor mass and tumor volume by four-fold, without any increase in tumor angiogenesis.

"Antioxidants have been associated with cancer reducing effects—beta carotene, for example—but the mechanisms, the genetic evidence, has been lacking," Dr. Lisanti said. "This study provides the necessary genetic evidence that reducing oxidative stress in the body will decrease tumor growth."

Currently, anti-cancer drugs targeting oxidative stress are not used because is it commonly thought they will reduce the effectiveness of certain chemotherapies, which increase oxidative stress.

"We are not taking advantage of the available drugs that reduce oxidative stress and autophagy, including metformin, chloroquine and N-acetyl cysteine," Dr. Lisanti said. "Now that we have genetic proof that oxidative stress and resulting autophagy are important for driving tumor growth, we should re-consider using antioxidants and autophagy inhibitors as anti-cancer agents."

The diabetic drug metformin and chloroquine, which is used for the prevention and treatment of malaria, prevent a loss of Cav-1 in cancer associated fibroblasts (which is due to oxidative stress), functionally cutting off the fuel supply to cancer cells.

This research also has important implications for understanding the pathogenesis of triple negative and tamoxifen-resistance in ER-positive breast caner patients, as well as other epithelial cancers, such as prostate cancers.

"Undoubtedly, this new genetically tractable system for cancer associated fibroblasts will help identify other key genetic 'factors' that can block tumor growth," Dr. Lisanti said. ... 021011.php

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Change diet, lifestyle, and keep cancer away

BANGALORE: There could be hope for cancer prevention in some of the most unassuming substances right in the kitchen -- oncologists are now betting on the age-old turmeric for head and neck cancer, some extracts of green tea, which are rich in antioxidants, and aspirin. A lot of research will start on aspirin and its role in colon cancer prevention, they say.

Another major area of research is lifestyle modification -- some cancers like breast cancer, cervical cancer and lung cancer can be greatly impacted by lifestyle modification, according to doctors.

The Mazumdar Shaw Cancer Centre (MSCC) has already completed randomized clinical trials on 220 oral cancer patients, by giving them doses of curcumin or turmeric. The data will be analyzed and results announced this March. Doctors here are also excited about aspirin.

"Clinical trials have not been done with aspirin, but there are a lot of studies abroad that are focusing on aspirin. Basically, most cancers are caused due to severe inflammation. Baby (mild dose) aspirin that soothes inflammation could have a potential impact. But we would have to prove it," said professor and director of the department of surgical oncology, and chief of head and neck oncology services, MSCC, Dr Moni Abraham Kuriakose.

He added that while clinical trials of green tea, as a whole, did not yield positive results in cancer prevention, some extracts of green tea could prove useful, according to studies done abroad.

But one major thing that all doctors are suggesting as a preventive strategy is lifestyle and diet change. According to chairman and chief executive officer, HCG, Ajai Kumar: "Breast cancer is highly preventable, provided one follows a certain kind of lifestyle and diet. Women who are on a low-fat diet, high on vegetables and fruits, and who do not smoke, are much less vulnerable even if it runs in the family. The cancer burden in India is so huge that technology alone cannot help, cancer incidence itself has to come down to stop India from being the number one in cancer incidence. People need to stop smoking, chewing tobacco and consuming alcohol. There is no other option," he said. Cervical cancer, which is becoming common in women, is also preventable if they have a good knowledge of hygiene measures and how the infection could spread. Cervical cancer is being seen more in rural women.

"Lifestyle factors are responsible for 85 of 100 cancer cases. It is a big load. In fact, even while we blame it on the genes, the genetic disorder comes from lifestyle factors. It has been clearly proved that in 95% of mouth cancer, tobacco chewing is a cause. Smoking, together with alcohol consumption, is a deadly combination and can increase the chances of a person getting cancer by eight times. It is also well established that contracting of the human papillo virus (HPV) -- that causes cervical cancer -- could happen from multiple partners," explained director of Kidwai Institute of Oncology, Dr M Vijay Kumar.

Investment in preventive measures in much higher because of the huge load of patients who are already affected. Dr Kumar added that no magic pill of prevention has yet been found, but things like mild forms of aspirin could have an impact. It is said to inhibit angiogenesis (process of growth of new blood vessels from pre-existing vessels).


* 100 out of 100,000 people in Bangalore have cancer

* 75% of cancers are due to lifestyle factors

* Breast cancer, cervical cancer, prostrate cancer and ovarian cancer increasingly becoming manageable

* Around 1 million cases of cancer surface in India every year. It is likely to go up to 2 million by 2020

* Food rich in anti-oxidants could play a preventive role ... 421347.cms

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PostPosted: Fri Mar 04, 2011 9:25 am 
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Spice in curry may help treat cancer

TEL AVIV, Israel, March 3 (UPI) -- Turmeric, a bright yellow spice in curry and what makes mustard yellow, may help treat cancer in combination with an arthritis drug, U.S. researchers say.

Dr. Shahar Lev-Ari of Tel Aviv University's School of Public Health at the Sackler Faculty of Medicine and colleagues found that curcumin -- turmeric's active ingredient -- can fight cancer when used in combination with a popular anti-inflammatory drug used to treat arthritis -- Celecoxib, which also inhibits proliferation of colon cancer in laboratory settings -- in alleviating the inflammatory response caused when cancer takes root in the body. The treatment has had promising results in human clinical trials, the researchers say.

"Although more testing will be needed before a possible new drug treatment is developed, one could combine curcumin with a lower dose of a cancer anti-inflammatory drug, to better fight colon cancer," Lev-Ari says in a statement.

Curcumin increases the anti-cancer and anti-inflammatory effects of Celecoxib while reducing its dose -- reducing its toxic side-effects, Lev-Ari says.

"We would like to use this treatment for patients with all types of cancers," says Nadir Arber of the Sackler Faculty of Medicine says.

"It has the promise of being an important life-extending therapy, particularly for non-curable pancreatic cancer, suggested by the very promising results we achieved for 20 pancreatic cancer patients."

The findings are published in the journal Therapeutic Advances in Gastroenterology. ... 299165520/

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